# iovera° Professional (ioverapro.com)

> ioverapro.com is the healthcare professional (HCP) resource for the iovera° cryoneurolysis system by Pacira BioSciences, Inc. The iovera° system is an FDA-cleared, non-surgical, drug-free treatment that delivers immediate pain relief up to 90 days by applying focused cold to peripheral nerves. This site provides clinical data, reimbursement guidance, training resources, and device information for healthcare professionals.

## About iovera°

- [What is iovera°](https://www.ioverapro.com/what-is-iovera): A handheld device that provides targeted, long-lasting pain relief through cryoneurolysis. Cryoneurolysis is the freezing of the signal-carrying parts of a nerve.
- [Appropriate Patients](https://www.ioverapro.com/appropriate-patients): Patient selection guidance for OA knee pain, pre-TKA prehabilitation and TKA recovery, and other areas of the body including hip, rib, shoulder, foot and ankle, spine, head and neck, and mastectomy.
- [The iovera° System](https://www.ioverapro.com/iovera-system): The iovera° system with Smart Tip technology — three different Smart Tips give health care providers the flexibility to decide how to perform the treatment.

## How It Works

- [How iovera° Works](https://www.ioverapro.com/how-iovera-works): The iovera° system uses N₂O, which does not reach temperatures cold enough to cause irreversible nerve damage. During each treatment cycle, liquid N₂O flows into the attached Smart Tip, where it expands into a gas creating a cold zone around the nerve.
- [Mechanism of Action](https://www.ioverapro.com/mechanism-of-action): See how iovera° therapy works on the nerves that transmit pain signals. The cold zone causes degeneration of axon and myelin sheath, temporarily blocking nerve signals.
- [Comparison of Nerve Treatments](https://www.ioverapro.com/comparison-of-nerve-treatments): Compared with cryoablation and cooled/conventional radiofrequency (RF), iovera° sits in a sweet spot at -88°C cryoneurolysis with 2nd degree Sunderland Classification nerve degeneration.

## Clinical Data

- [OA Clinical Efficacy Data](https://www.ioverapro.com/oa-clinical-efficacy-data): Up to 56% reduction in WOMAC pain scores from baseline. Randomized, double-blind, sham-controlled, multicenter trial. Radnovich R et al. Osteoarthritis Cartilage. 2017;25(8):1247-1256.
- [TKA Clinical Efficacy Data](https://www.ioverapro.com/tka-clinical-efficacy-data): Less pain, fewer opioids. 45% reduction in opioid consumption during the 12 weeks following surgery. Dasa V et al. Knee. 2016;23(3):523-528.

## Reimbursement & Practice

- [Reimbursement & Ordering](https://www.ioverapro.com/reimbursement): Cryoneurolysis with iovera° is reimbursed in the Hospital Outpatient Department, Ambulatory Surgery Center, and Physician Office. CPT 64640 for peripheral nerve branches. CPT 64624 for genicular nerve branches including imaging.
- [NOPAIN Act](https://www.ioverapro.com/nopain-act): The NOPAIN (Non-Opioids Prevent Addiction in the Nation) Act was enacted to expand access to non-opioid pain treatments for Medicare patients. As of January 1, 2025, iovera° is officially recognized as a qualifying non-opioid device eligible for separate Medicare reimbursement. HCPCS Code C9809.
- [FlexForward Overview](https://www.ioverapro.com/flexforward): FlexForward® is designed to help you get commercial and Medicare Advantage patients started with iovera°. It provides comprehensive reimbursement support through benefits investigation help, prior authorization and appeals support, and coding and billing assistance.

## Educational Resources

- [Video Library](https://www.ioverapro.com/video-library): Training and educational videos for healthcare professionals on iovera° treatment techniques and clinical applications.
- [Recorded Hands-On Training](https://www.ioverapro.com/training): Recorded hands-on training videos for healthcare professionals on iovera° treatment techniques.
- [Administrative Case Reports](https://www.ioverapro.com/administrative-case-reports): Administrative case reports and clinical documentation examples for healthcare providers.
- [Peer Testimonials](https://www.ioverapro.com/peer-testimonial): Hear from physicians using iovera° in clinical practice. Real-world implementation insights and practitioner perspectives.
- [Practice Toolkit](https://www.ioverapro.com/practice-toolkit): The iovera° Practice Toolkit includes a variety of resources designed to help educate patients and promote iovera° for your practice.

## Additional Resources

- [FAQ](https://www.ioverapro.com/faq): Frequently asked questions in 8 categories: New to iovera°, Mechanism of Action, Results, Patient considerations, Device, Cost and coverage, General reimbursement information, and Insurance/payer information.
- [Find a Doctor Registration](https://www.ioverapro.com/find-a-doctor-registration): Sign up for the iovera° Find a Doctor Program to make it easier for patients in your area to find you.
- [Schedule a Demo](https://www.ioverapro.com/schedule-demo): Get a personalized iovera° demo tailored to your specialty and patient needs.
- [Instructions for Use](https://www.ioverapro.com/instructions-for-use): Carefully read all instructions prior to using the iovera° system.
- [Contact Us](https://www.ioverapro.com/contact-us): Contact Pacira for iovera° professional support.
- [Medial Branch](https://www.ioverapro.com/medial-branch): The iovera° Spine Smart Tip is designed to target medial branch nerves to provide immediate, long-lasting relief from chronic back pain.
- [Pain with Spasticity](https://www.ioverapro.com/pain-with-spasticity): Managing pain associated with spasticity may positively impact the quality of life and well-being of patients.

## Important Safety Information

**Indication:** The iovera° system is used to destroy tissue during surgical procedures by applying freezing cold. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain. It is also indicated for the relief of pain and symptoms associated with osteoarthritis of the knee for up to 90 days. The iovera° system is not indicated for treatment of central nervous system tissue.

When stimulation compatible components are used, the iovera° system can also facilitate target nerve location by conducting electrical nerve stimulation from a compatible 3rd party nerve stimulator.

**Contraindications:** The iovera° system is contraindicated for use in patients with cryoglobulinemia, paroxysmal cold hemoglobinuria, cold urticaria, Raynaud's disease, and open and/or infected wounds at or near the treatment site.

**Potential Complications:** As with any surgical treatment that uses needle-based therapy and local anesthesia, there is a potential for site-specific reactions, including, but not limited to: ecchymosis, edema, erythema, local pain and/or tenderness, and localized dysesthesia. Proper use of the device as described in the User Guide can help reduce or prevent the following complications: at the treatment site(s) — injury to the skin related to application of cold or heat, hyper- or hypopigmentation, and skin dimpling; outside the treatment site(s) — loss of motor function.

For full prescribing information, see the [Instructions for Use](https://www.ioverapro.com/instructions-for-use).