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Achieve immediate and long-lasting relief of OA or TKA knee pain with targeted cryoneurolysis1-3

DISCOVER iovera° discover button

Achieve immediate and long-lasting relief of OA or TKA knee pain with targeted cryoneurolysis1-3

DISCOVER iovera° discover button
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Non-surgical, drug-free treatment delivers what your patients need:

  • calendar icon

    Immediate pain relief up to 90 days3

  • opioid icon

    Less opioid
    use1

  • range icon

    Improved range of
    motion post-TKA4

  • simple safe icon

    Simple and safe—
    FDA-cleared

In addition, iovera° has a broad indication and is commonly used to treat pain in other areas:

  • Hip
  • Rib
  • Shoulder
  • Foot and ankle
  • Spine
  • Head and neck
  • Mastectomy
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Learn how iovera° may help your patients

See CLINICAL DATA in Oa
knee pain See results in
PRE-TKA AND POST-TKA

AAOS=American Academy of Orthopaedic Surgeons; CPG=clinical practice guidelines; FDA=US Food and Drug Administration; OA=osteoarthritis; TKA=total knee arthroplasty.

References: 1. Dasa V et al. Knee. 2016;23(3):523-528. 2. Data on file. Pacira BioSciences, Inc.; 2021. 3. Radnovich R et al. Osteoarthritis Cartilage. 2017;25(8):1247-1256.
4. Plessl D et al. J Am Acad Orthop Surg. 2020;28(21):e962-e968.

Indication

The iovera° system is used to destroy tissue during surgical procedures by applying freezing cold. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain. It is also indicated for the relief of pain and symptoms associated with osteoarthritis of the knee for up to 90 days. The iovera° system is not indicated for treatment of central nervous system tissue.

When stimulation compatible components are used, the iovera° system can also facilitate target nerve location by conducting electrical nerve stimulation from a compatible 3rd party nerve stimulator.

Important Safety Information

Contraindications

The iovera° system is contraindicated for use in patients with the following:

  • Cryoglobulinemia, paroxysmal cold hemoglobinuria, cold urticaria, Raynaud’s disease, and open and/or infected wounds at or near the treatment site

Potential Complications

As with any surgical treatment that uses needle-based therapy and local anesthesia, there is a potential for site-specific reactions, including, but not limited to:

  • Ecchymosis, edema, erythema, local pain and/or tenderness, and localized dysesthesia

Proper use of the device as described in the User Guide can help reduce or prevent the following complications:

  • At the treatment site(s): injury to the skin related to application of cold or heat, hyper- or hypopigmentation, and skin dimpling
  • Outside the treatment site(s): loss of motor function
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Indication

The iovera° system is used to destroy tissue during surgical procedures by applying freezing cold. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain.

Important Safety Information