The iovera° system uses N2O, which does not reach temperatures cold enough to cause irreversible nerve damage
- Liquid N2O cartridge is inserted into the Handpiece; each cartridge >850 psi
- During each treatment cycle, liquid N2O flows into the attached Smart Tip, where it expands into a gas. The iovera° system uses the body's own fluids to form a precise cold zone around the nerve. N2O boils at -88°C, which is the coldest temperature that can be attained with iovera°
- N20 safely exits as a gas; needles are closed-ended so nothing is injected into the body
Drawing not to scale. For illustrative purposes only.
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Additional Information
Pacira Pharmaceuticals, Inc.
A subsidiary of Pacira Biosciences, Inc.
10410 Science Center Drive, Building A
San Diego, CA 92121 U.S.A
Legal Disclaimer
Zimmer Biomet acquired the iovera° business from Pacira BioSciences, Inc. on 31 Jul 2026, obtaining contractual agreement for the development, manufacture, and commercialization of iovera°.
During the transition period under the applicable Transition Services Agreement, Pacira remains the legal manufacturer for applicable iovera° products and retains the related regulatory responsibilities.
Zimmer Biomet acts as a contracted service provider, performing certain design, manufacturing, quality, and post-market activities under Pacira's quality system and oversight until the transition is complete.