Compared with cryoablation and cooled/ conventional radiofrequency (RF), iovera° sits in a “sweet spot” at -88°c cryoneurolysis

  • Cold enough to produce an immediate, long-lasting neurolytic block on the axon and myelin sheath of a peripheral nerve1
    • 2nd degree (-100°C to -20°C) Sunderland Classification nerve degeneration
  • Unlike cryoablation, the cold is not too extreme to affect the structural components of the nerve
    • The axon regenerates along its original pathway at a rate of 1 to 2 mm per day until nerve signaling is fully restored2

Comparison of nerve treatments

    • Cryoablation provides irreversible nerve degeneration via liquid nitrogen3

      Previous navigation arrow-140°C

    • Cryoneurolysis provides immediate treatment effect without permanently destroying nerves4

      -88°C

    • Pulsed RF1

      40°C

    • RF risks neuroma formation postdenervation, neuritis, and injury to nearby tissue and vessels3

    • Cooled/Conventional RF5

      60°C to 80°C

For more detail, download the Comparative Technology guide.

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  • References:
  • 1. Hsu M, Stevenson FF. Muscle Nerve. 2015;51(2):268-275.
  • 2. Ilfeld BM et al. Expert Rev Med . 2016;13(8):713-725.
  • 3. Zhou L et al.
    J Analgesics. 2014;2(1):16-22.
  • 4. Barnard D. Ann R Coll Surg. 1980;62(3):180-187.
  • 5. Cosman ER Jr, Dolensky JR, Hoffman RA. Pain Med. 2014;15(12):2020-2036.

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Additional Information

Pacira Pharmaceuticals, Inc.

A subsidiary of Pacira Biosciences, Inc.

10410 Science Center Drive, Building A

San Diego, CA 92121 U.S.A

Legal Disclaimer

Zimmer Biomet acquired the iovera° business from Pacira BioSciences, Inc. on 31 Jul 2026, obtaining contractual agreement for the development, manufacture, and commercialization of iovera°.

During the transition period under the applicable Transition Services Agreement, Pacira remains the legal manufacturer for applicable iovera° products and retains the related regulatory responsibilities.

Zimmer Biomet acts as a contracted service provider, performing certain design, manufacturing, quality, and post-market activities under Pacira's quality system and oversight until the transition is complete.