Compared with cryoablation and cooled/ conventional radiofrequency (RF), iovera° sits in a “sweet spot” at -88°c cryoneurolysis
- Cold enough to produce an immediate, long-lasting neurolytic block on the axon and myelin sheath of a peripheral nerve1
- 2nd degree (-100°C to -20°C) Sunderland Classification nerve degeneration
- Unlike cryoablation, the cold is not too extreme to affect the structural components of the nerve
- The axon regenerates along its original pathway at a rate of 1 to 2 mm per day until nerve signaling is fully restored2
Comparison of nerve treatments
-
-140°C- -88°C
-
-
Cryoablation provides irreversible nerve degeneration via liquid nitrogen3
-140°C
-
Cryoneurolysis provides immediate treatment effect without permanently destroying nerves4
-88°C
-
-
- 40°C
- 60°C to 80°C
-
-
Pulsed RF1
40°C -
RF risks neuroma formation postdenervation, neuritis, and injury to nearby tissue and vessels3
-
Cooled/Conventional RF5
60°C to 80°C
-
For more detail, download the Comparative Technology guide.
- References:
- 1. Hsu M, Stevenson FF. Muscle Nerve. 2015;51(2):268-275.
- 2. Ilfeld BM et al. Expert Rev Med
. 2016;13(8):713-725. - 3. Zhou L et al.
J Analgesics. 2014;2(1):16-22. - 4. Barnard D. Ann R Coll Surg. 1980;62(3):180-187.
- 5. Cosman ER Jr, Dolensky JR, Hoffman RA. Pain Med. 2014;15(12):2020-2036.