Ice treatment device on the left side

COMPARED WITH CRYOABLATION AND COOLED/ CONVENTIONAL RADIOFREQUENCY (RF), iovera° SITS IN A “SWEET SPOT” AT -88°C CRYONEUROLYSIS

  • Cold enough to produce an immediate, long-lasting neurolytic block on the axon and myelin sheath of a peripheral nerve1
    • 2nd degree (-100°C to -20°C) Sunderland Classification nerve degeneration
  • Unlike cryoablation, the cold is not too extreme to affect the structural components of the nerve
    • The axon regenerates along its original pathway at a rate of 1 to 2 mm per day until nerve signaling is fully restored2

Comparison of nerve treatments

    • Cryoablation provides irreversible nerve degeneration via liquid nitrogen3

      less then arrow-140°C

    • Cryoneurolysis provides immediate treatment effect without permanently destroying nerves4

      -88°C

    • Pulsed RF1

      40°C

    • RF risks neuroma formation postdenervation, neuritis, and injury to nearby tissue and vessels3

    • Cooled/Conventional RF5

      60°C to 80°C

For more detail, download the Comparative Technology guide.

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References: 1. Hsu M, Stevenson FF. Muscle Nerve. 2015;51(2):268-275. 2. Ilfeld BM et al. Expert Rev Med . 2016;13(8):713-725. 3. Zhou L et al.
J Analgesics. 2014;2(1):16-22. 4. Barnard D. Ann R Coll Surg. 1980;62(3):180-187. 5. Cosman ER Jr, Dolensky JR, Hoffman RA. Pain Med. 2014;15(12):2020-2036.

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Reduce OA knee pain

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Indication

The iovera° system is used to destroy tissue during surgical procedures by applying freezing cold. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain. It is also indicated for the relief of pain and symptoms associated with osteoarthritis of the knee for up to 90 days. The iovera° system is not indicated for treatment of central nervous system tissue.

When stimulation compatible components are used, the iovera° system can also facilitate target nerve location by conducting electrical nerve stimulation from a compatible 3rd party nerve stimulator.

Important Safety Information

Contraindications

The iovera° system is contraindicated for use in patients with the following:

  • Cryoglobulinemia, paroxysmal cold hemoglobinuria, cold urticaria, Raynaud’s disease, and open and/or infected wounds at or near the treatment site

Potential Complications

As with any surgical treatment that uses needle-based therapy and local anesthesia, there is a potential for site-specific reactions, including, but not limited to:

  • Ecchymosis, edema, erythema, local pain and/or tenderness, and localized dysesthesia

Proper use of the device as described in the User Guide can help reduce or prevent the following complications:

  • At the treatment site(s): injury to the skin related to application of cold or heat, hyper- or hypopigmentation, and skin dimpling
  • Outside the treatment site(s): loss of motor function
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Indication

The iovera° system is used to destroy tissue during surgical procedures by applying freezing cold. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain.

Important Safety Information