A handheld device that provides targeted, long-lasting pain relief through Cryoneurolysis

Cryoneurolysis is the freezing of the signal-carrying parts of a nerve

The iovera° system creates a “cold zone” that blocks nerve signals and immediately reduces pain—without the use of drugs*:

Targeted treatment icon

Targeted cold is applied directly to a peripheral nerve

Medication reduction icon

The iovera° treatment does
not include the injection of opioids

90-day duration icon

Pain relief can last up to 90 days per treatment1

Cold zone treatment area icon

iovera° uses nitrous oxide and the body’s own fluid to create a precise cold zone under the skin cold enough to immediately prevent the nerve from sending pain signals without causing damage to the surrounding structures

Treatment time icon

The effect on the nerve is temporary, providing pain relief until the nerve regenerates and function is restored

Cryoneurolysis with iovera° provides targeted pain relief without permanently damaging nerves

iovera treatment application image 1

1

Treatment

Cold zone is created around the targeted nerve, reaching a temperature of -88°C

iovera treatment application image 2

2

Degeneration

Cold zone causes degeneration of axon and myelin sheath, temporarily blocking nerve signals

iovera treatment application image 3

3

Regeneration

Following treatment,
the axon regenerates at about 1 to 2 mm/day2

iovera treatment application image 4

4

Reinnervation

The axon and myelin sheath are fully regenerated, and nerve signaling is restored

*iovera° therapy does not treat the underlying cause of the pain; timely remediation is necessary to address the root cause.

  • References:
  • 1. Radnovich R et al. Osteoarthritis Cartilage. 2017;25(8):1247-1256.
  • 2. Evans PJ et al. Br J Anaesth. 1981;53(11):1121-1127.

See iovera°
in action

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Who can benefit from
treatment with iovera°?

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