A handheld device that provides targeted, long-lasting pain relief through Cryoneurolysis
Cryoneurolysis is the freezing of the signal-carrying parts of a nerve
The iovera° system creates a “cold zone” that blocks nerve signals and immediately reduces pain—without the use of drugs*:
Targeted cold is applied directly to a peripheral nerve
The iovera° treatment does
not include the injection of opioids
Pain relief can last up to 90 days per treatment1
iovera° uses nitrous oxide and the body’s own fluid to create a precise cold zone under the skin cold enough to immediately prevent the nerve from sending pain signals without causing damage to the surrounding structures
The effect on the nerve is temporary, providing pain relief until the nerve regenerates and function is restored
Cryoneurolysis with iovera° provides targeted pain relief without permanently damaging nerves
1
Treatment
Cold zone is created around the targeted nerve, reaching a temperature of -88°C
2
Degeneration
Cold zone causes degeneration of axon and myelin sheath, temporarily blocking nerve signals
3
Regeneration
Following treatment,
the axon regenerates
at about 1 to 2 mm/day2
4
Reinnervation
The axon and myelin sheath are fully regenerated, and nerve signaling is restored
*iovera° therapy does not treat the underlying cause of the pain; timely remediation is necessary to address the root cause.
- References:
- 1. Radnovich R et al. Osteoarthritis Cartilage. 2017;25(8):1247-1256.
- 2. Evans PJ et al. Br J Anaesth. 1981;53(11):1121-1127.
See iovera°
in action
Who can benefit from
treatment with iovera°?
Additional Information
Pacira Pharmaceuticals, Inc.
A subsidiary of Pacira Biosciences, Inc.
10410 Science Center Drive, Building A
San Diego, CA 92121 U.S.A
Legal Disclaimer
Zimmer Biomet acquired the iovera° business from Pacira BioSciences, Inc. on 31 Jul 2026, obtaining contractual agreement for the development, manufacture, and commercialization of iovera°.
During the transition period under the applicable Transition Services Agreement, Pacira remains the legal manufacturer for applicable iovera° products and retains the related regulatory responsibilities.
Zimmer Biomet acts as a contracted service provider, performing certain design, manufacturing, quality, and post-market activities under Pacira's quality system and oversight until the transition is complete.